| c. 480 BCE | Battle of Himera (Wars and conquests)#60, 61 | A victory where Gelon of Syracuse crushes Hamilcar's Carthaginians. |
| c. 480 BCE?–c. 406 BCE | Euripides (People)#62, 63 | Athenian writer of tragedies, author of Medea and The Bacchae. |
| c. 480 BCE–323 BCE | Classical period (Periods, states and leagues)#64, 65 | The age of Athenian democracy, the Peloponnesian War, drama and philosophy. |
| 480 BCE | Battle of Salamis (Wars and conquests)#66, 67 | Themistocles leads the Greek fleet to victory in the Saronic Gulf. |
| 480 BCE | Battle of Thermopylae (Wars and conquests)#68, 69 | Leonidas' Greeks hold the pass; Persia takes the victory. |
| 479 BCE | Battle of Plataea (Wars and conquests)#70, 71 | A Greek army led by Sparta defeats Mardonius. |
| 478 BCE–404 BCE | Delian League (Periods, states and leagues)#72, 73 | Alliance led by Athens against Persia; it grew into an Athenian empire. |
| c. 469 BCE–399 BCE | Socrates (People)#74, 75 | Athenian philosopher put on trial and executed by his own city. |
| c. 460 BCE?–c. 400 BCE | Thucydides (People)#76, 77 | Athenian general who chronicled the Peloponnesian War. |
| c. 460 BCE–c. 370 BCE | Hippocrates (People)#78, 79 | Physician from Kos who split medicine apart from philosophy. |
| 458 BCE | Oresteia (Culture, art and religion)#80, 81 | Aeschylus' trilogy of tragedies, winner of the top prize at the Dionysia. |
| 447 BCE–432 BCE | Construction of the Parthenon (Culture, art and religion)#82, 83 | Temple of Athena on Athens' Acropolis, designed by Ictinus and Callicrates. |
| 431 BCE–404 BCE | Peloponnesian War (Wars and conquests)#84, 85 | Athens against Sparta; ends with Athens' surrender in 404. |
| 430 BCE–426 BCE? | Plague of Athens (Wars and conquests)#86, 87 | An epidemic that killed a large share of the population of Athens. |
| c. 428 BCE?–c. 347 BCE | Plato (People)#88, 89 | Athenian philosopher who founded the Academy and wrote the Dialogues. |
| c. 420 BCE?–362 BCE | Epaminondas (People)#90, 91 | Theban general, won at Leuctra. |
| 415 BCE–413 BCE | Sicilian Expedition (Wars and conquests)#17, 92 | Athens loses its fleet and army at Syracuse. |
| 399 BCE | Trial and death of Socrates (Philosophy, science and history writing)#74, 93 | Convicted of impiety at Athens; he is put to death with hemlock. |
| c. 387 BCE? | Plato founds the Academy (Philosophy, science and history writing)#94, 95 | Plato's school near Athens. |
| 384 BCE–322 BCE | Aristotle (People)#96, 97 | Philosopher and scientist who taught Alexander and founded the Lyceum. |
| 382 BCE–336 BCE | Philip II of Macedon (People)#98, 99 | Father of Alexander and king of Macedon; assassinated. |
| c. 375 BCE–316 BCE | Olympias (People)#100, 101 | Princess of Epirus, wife of Philip II and mother of Alexander |
| 371 BCE | Battle of Leuctra (Wars and conquests)#102, 103 | Epaminondas leads Thebes to victory over Sparta. |
| 371 BCE–362 BCE | Theban hegemony (Politics, colonies and reforms)#104, 105 | Epaminondas makes Thebes the leading power in Greece. |
| c. 366 BCE–282 BCE? | Ptolemy I Soter (People)#106, 107 | Alexander's general, founded Ptolemaic Egypt. |
| c. 358 BCE?–281 BCE | Seleucus I Nicator (People)#108, 109 | A general of Alexander who went on to found the Seleucid Empire. |
| 356 BCE–323 BCE | Alexander the Great (People)#110, 111 | King of Macedon who conquered the Persian Empire. |
| 341 BCE–270 BCE | Epicurus (People)#112, 113 | From Samos, he founded the Epicurean school in Athens. |
| August 338 BCE | Battle of Chaeronea (Wars and conquests)#114, 115 | Athens and Thebes fall to Philip II; Greece passes under Macedon. |
| 337 BCE? | League of Corinth (Politics, colonies and reforms)#116, 117 | Greek states bound into an alliance under Philip II of Macedon. |
| 335 BCE | Aristotle founds the Lyceum (Philosophy, science and history writing)#96, 118 | The Peripatetic school Aristotle established in Athens. |
| c. 334 BCE–c. 262 BCE | Zeno of Citium (People)#119, 120 | Cypriot philosopher; founded the Stoic school |
| 334 BCE–323 BCE | Alexander's Asian campaign (Wars and conquests)#110, 111 | Alexander conquers Persia and pushes on to India. |
| 331 BCE | Founding of Alexandria (Politics, colonies and reforms)#121, 122 | Alexander founds a port city in Egypt. |
| 1 October 331 BCE | Battle of Gaugamela (Wars and conquests)#123, 124 | Alexander defeats Darius III for the final time. |